Promethazine suppositories work quickly to relieve nausea, vomiting and provide sedation. They are available by prescription and come in a variety of forms.
Suppositories are intended for rectal use only. They are more slowly absorbed than oral solutions or i.m. injections and have a lower systemic bioavailability due to extensive first-pass hepatic metabolism. Dosage is usually lower for suppositories than for oral and i.m. injections, and children should receive only the minimum dose necessary to control symptoms.
Promethazine works by preventing the release of histamine from certain cells in your body. Histamine is a substance that causes allergy symptoms such as runny nose, sneezing, itchy or watery eyes, itching of the skin and hives. This medication also reduces stimulation of the part of the brain that causes you to vomit.
It is important to tell your doctor about all the medicines and supplements you are taking, including vitamins and herbs. Some medicines can interact with this drug and cause dangerous side effects. Your doctor may need to change your dose or prescribe a different medicine.
The safety of using this medication in children under 2 years has not been established. It is important to know that this medication can decrease the number of white blood cells in your body, which may increase your risk of getting infections. Talk to your doctor if you are receiving chemotherapy or other anticancer treatment, or if you have low levels of WBCs.