The Benefits of Estrogen

January 14, 2023

benefits of estrogen

The benefits of estrogen are not limited to just being a hormone. They also include many different aspects of your health, such as the neuro-logical system and cardiovascular system.

Cardiovascular disease

The benefits of estrogen in cardiovascular disease include its ability to reduce inflammation, improve the calcified plaque burden and improve vascular function. Estrogen has a protective effect on cardiovascular tissues in animal models.

In recent years, there has been a great deal of interest in estrogen's effects on cardiovascular tissues. There has been a growing body of research to investigate its impact on the pathogenesis of CVD.

Previously, studies in mice have shown that estrogen has an anti-ischemic effect. These effects may be due to its interaction with the endothelium through the estrogen receptor alpha (ERa). Angiogenesis is the process by which new blood vessels are formed. This is believed to be important for the prevention of early atherosclerosis.

In addition to these studies, a number of cohort studies have also reported cardioprotective effects of hormone therapy. However, the effect of estrogen on stroke risk remains unclear.


Estrogen is known as a hormone that plays a vital role in the health of bones and other tissues. It affects bone cells and also promotes osteoblast activity.

One of the most effective ways to prevent osteoporosis is to get enough calcium in your diet. Getting plenty of vitamin D is also important. A good blood test can determine your vitamin D levels.

Another approach is to take medications that can help your body absorb calcium and build strong, healthy bones. This can be done with hormone replacement therapy (HRT) or a medication called bisphosphonates.

Several studies have shown that estrogen can help prevent osteoporosis. The most important benefit is that it reduces the risk of fracture. However, it's unclear whether this effect will last for a lifetime.

Although estrogen may decrease the risk of fracture, it can cause non-fracture related complications. Hence, the benefits of estrogen therapy should be combined with other modalities.

Endometrial thickening

One of the benefits of estrogen is its ability to increase the thickness of the uterine lining. This could be helpful to women who want to avoid hysterectomy, if their endometrium is too thin. However, it is also important to consider the potential side effects and risks associated with hormone therapy. Those who are considering hormonal therapy should speak with their doctor.

In this study, women who were using low-dose vaginal estrogens to treat vulvar atrophy were compared to those who did not. Endometrial thickness was measured on day 10 +- 1 of treatment in both groups. The T group had a mean thickness of 9.9 mm, while the V group had a mean thickness of 8.3 mm.

Transdermal estrogen was correlated with higher endometrial thickness. Moreover, women who used transdermal estrogen had shorter treatment durations and fewer side effects.

Neurological system health

Oestrogen has long been recognized as a protective factor for the central nervous system. It has also been shown to be beneficial for cognition. During menopause, estrogen levels decrease. This may have an effect on gray matter volume and other cognitive functions.

Estrogens are believed to promote the repair of DNA and help modulate cell proliferation and differentiation. This may increase the longevity of cells and tissues and thus reduce the risk of dementia. They are also known to be anti-oxidants.

Recent studies have revealed that women experience significant GMV loss during menopause. Studies have linked this decline to reduced grey matter volumes. Other findings suggest that estrogens and hormone replacement therapy can benefit cognitive function.

One study showed that selective activation of the estrogen receptor ERb improved synaptic plasticity in the hippocampus. Another study showed that acetylcholinesterase inhibitors, which boost cholinergic synaptic signaling, could increase the effects of E2.

Studies have also shown that a selective E2 agonist, tacrine, potentiated the cognitive effects of E2. Other studies have suggested that a combination of hormones and neurotransmitters may produce even greater benefits.

Uterine cancer

Endometrial cancer is a genital tract cancer that is more prevalent in postmenopausal women. It is often associated with obesity and late menopause. Estrogen replacement therapy has been studied in endometrial cancer patients.

Estrogen can have a protective effect against uterine cancer, as it inhibits the growth of endometrial cells in the uterus. However, continued estrogen production may increase the risk of recurrence of endometrial cancer. The effects of estrogen on the progression of endometrial cancer have been investigated in case-control studies, randomized controlled trials, and clinical trials.

Exogenous hormones, such as tamoxifen, can also promote recurrence of uterine cancer. Other factors, such as age, body mass index, and reproductive history, have been linked to the development of uterine cancer.

The standard treatment for endometrial cancer includes bilateral salpingo-oophorectomy and total abdominal hysterectomy. Hormone adjuvant therapy is not beneficial in women after surgery. An alternative form of treatment is uterine-preserving therapy with progesterone.


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