This medication isn't safe to take with certain other medicines. You'll need to talk with your doctor or pharmacist before taking any other prescription, over-the-counter, or herbal medications.
You'll also need to tell your doctor if you have any bleeding problems or a history of blood clots (blood clots in your veins). If you have any of these, you may need to take extra medicine.
Other medicines that affect your CYP2D6 enzyme may increase the amount of this drug in your body and make it work less well. These medicines are called CYP2D6 inhibitors.
Some antidepressants, such as tricyclic antidepressants (TCAs), may interact with Trintellix. When you take this medication with these drugs, it can increase your risk of serotonin syndrome. This can be serious and even life-threatening.
Your doctor may need to monitor you more often for serotonin syndrome if you take this medication with TCAs. They can do this by watching your symptoms, such as anxiety, hallucinations, sweating, and muscle spasms.
Alcohol can also affect how this medication works in your body. It can cause an increased risk of side effects, including nausea, vomiting, and loss of appetite.
The FDA has issued a warning about these possible interactions. If you are taking any of these medicines, your doctor or pharmacist will be able to tell you if they can be taken safely with Trintellix.
Other things you can't take with this medication include glaucoma and medications for mania. These medicines can lower your ability to respond to this drug and increase your risk of other side effects.