Monday Night Football has been a mainstay on the NFL's broadcast schedule since its inception. Over the years, it has seen its share of changes and controversy. The biggest change came in the booth in 2018. Jon Gruden left MNF after 9 seasons and returned to coaching with the Oakland Raiders. ESPN's Sean McDonough and Joe Tessitore traded places, with McDonough moving to the college booth and Tessitore taking over the MNF booth.

Despite the changes, Monday Night Football continues to have some of the best talent in the business behind the microphone. The network has also made use of MNF to promote its other properties and brands, including releasing a trailer for the 2015 film Star Wars during one broadcast and using the Muppets in another.

The first week of the season saw a new opening sequence. Hank Williams Jr. returned to the telecast for an all-new version of his song "All My Rowdy Friends Are Here on Monday Night" that was shown before the New Orleans Saints-Minnesota Vikings game. The video was a collaboration between the country artist, Florida Georgia Line, and R&B singer Jason Derulo.

The first game of the season saw an event that changed MNF forever. Buffalo Bills safety Damar Hamlin collapsed on the field after making a tackle and was not able to return to the game. The game was delayed for several minutes while authorities tried to determine what had happened. Eventually, it was announced that Hamlin had suffered a cardiac arrest and was being transported to the University of Cincinnati Medical Center.